Did you know acetaminophen lowers glutathione levels? Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Tylenol & Glutathione What Parents Need to Know! , I get it, many parents are concerned about giving their child Tylenol (acetaminophen) because it can lower glutathione, a crucial antioxidant that The Hidden Impact of Acetaminophen Well Rooted Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: