Psychopharmacology Debates: Tylenol or NSAIDs? Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione recycling and its importance in detoxification Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health