How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Tylenol depletes something called glutathione. Glutathione is a master antioxidant and your first line of protection against environmental toxins. It detoxifies and protects your cells. It protects your immune system and Tylenol and Glutathione: A Closer Look At Their Relationship Sex differences in glutathione metabolism and acetaminophen toxicity Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Acetaminophen (Paracetamol) Journal of Pain and Symptom Management