I've had a migraine since Sept 4th. I took a B12 injection that day (prescribed by my doctor) so I'm wondering if it's related or coincidence. I'm scared to take another one Vitamin B12 Deficiency and Migraine Cerebral Torque Can Vaccines Cause Headaches or Migraine? American Migraine Foundation Botox for Migraine Treatment in Winter Park, FL Wednesday Neuro Tip Botox Injection for Migraine: Botox is an FDA approved chronic treatment for chronic migraine that involves a series of injections into the muscles of the head and neck Vitamin B12 injections deliver high doses of this essential vitamin directly into your bloodstream for better absorption than oral supplements to boost energy, support red blood cell production and maintain nerve function.