Glutathione or L Glutathione: What is Better for Skin? Acetaminophen toxicity EMCrit Project 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body.