Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network NAPQI Wikipedia Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Correct Answer: B. N acetylcysteine (NAC) Why is this High Yield? Acetaminophen (Paracetamol) is widely used, making toxicity a common ER presentation. 1. Mechanism of Toxicity: Acetaminophen is metabolized in the liver. Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.