Paracetamol (Acetaminophen) hepatotoxicity and its management. NAPQI (N Acetyl 4 benzoquinone Imine) Acetaminophen Metabolite MedChemExpress Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Biotransformations Leading to Toxic Metabolites: Chemical Aspects ScienceDirect Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research