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5-oxoproline glutathione View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis
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5-oxoproline glutathione View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis
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Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen The American Journal of the Medical Sciences Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Acquired pyroglutamic acidaemia in a critically ill patient with chronic paracetamol use: A case report Lee Connolly, Ed Briggs, 2022 Full article: What is the clinical significance of 5 oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? HPLCMS MS methods for the quantitative analysis of 5 oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium ScienceDirect Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione deplet Integrative Biology (RSC Publishing) DOI:10.1039 C3IB20245C
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5-oxoproline glutathione View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis
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