Acetaminophen induced S nitrosylation and S sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids Toxicology Research (RSC Publishing) ACETAMINOPHEN INDUCED HEPATOTOXICITY Drug Metabolism and Disposition Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit