MOTRIN PM Pain Relief Caplets MOTRIN Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Tylenol and Alcohol: Liver Damage Risks & Safety Tips Gratitude Lodge Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.